A Review: Benefit of Pereskia bleo (Kunth) DC Leaves
Main Article Content
Abstract
Background of study: Pereskia bleo (Kunth) DC, commonly known as Daun tujuh jarum, is a leafy cactus traditionally used in South America, Southeast Asia, and other tropical regions for treating various ailments, including cancer, diabetes, hypertension, ulcers, inflammation, and rheumatism. Its leaves are commonly consumed raw, boiled, or prepared as tea and juice. In recent years, scientific interest in P. bleo has increased due to its rich antioxidant content, diverse phytochemicals, and promising therapeutic potential. Studies have identified proteins, essential amino acids, flavonoids, alkaloids, sterols, and phenolic compounds that may contribute to its health benefits.
Aims and scope of paper: This review aims to summarize the traditional uses, nutritional value, phytochemical composition, and pharmacological activities of Pereskia bleo leaves, with particular emphasis on their antioxidant and medicinal properties. Applications in food, health, and traditional medicine are discussed, along with potential safety concerns.
Methods: A literature-based approach was employed, drawing on ethnopharmacological surveys, phytochemical investigations, and pharmacological studies to evaluate the properties and biological effects of the plant.
Result: The findings indicate that P. bleo leaves possess antioxidant, anticancer, antimicrobial, and anti-inflammatory activities. Several studies report strong cytotoxic effects against cancer cell lines, high nutritional value, and low toxicity in animal models, with only mild adverse effects documented in humans.
Conclusion: Pereskia bleo demonstrates considerable potential as a natural antioxidant, antimicrobial, and anticancer agent. Although generally considered safe, its use should be approached with caution due to possible herb–drug interactions, and further clinical studies are required to confirm its efficacy and safety
Downloads
Article Details
Copyright (c) 2025 Natasya Hermawan, Sephira Odelia, Lisa Angereni, Leonid Fornaris Castro

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
References
Abbdewahab, S. I., Ain, N. M., Abdul, A. B., Taha, M. M. E. & Ibrahim, T. A. T. (2009). Energy-dispersive X-ray microanalysis of elements’ content and antimicrobial properties of Pereskia bleo and Goniothalamus umbrosus. African Journal of Biotechnology, 8(10), 2375-2378. https://doi.org/10.5897/AJB09.028
Abdul-Wahab, I. R., Guilhon, C. C., Fernandes, P. D. and Boylan, F. (2012). Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts. Journal of Ethnopharmacology, 144(3), 741-746. https://doi.org/10.1016/j.jep.2012.10.029
Amaral, D. T., Bonatelli, I. A. S., Romeiro-Brito, M. Moraes, E. M. and Franco, F. F. (2022). Spatial patterns of evolutionary diversity in Cactaceae show low ecological representation within protected areas. Biological Conservation, 273, 109677. https://doi.org/10.1016/j.biocon.2022.109677
Carlsen, M. H., Halvorsen, B. L., Holte, K., Bøhn, S. K., Dragland, S., Sampson, L., Willey, C., Senoo, H., Umezono, Y., Sanada, C., Barikmo, I., Berhe, N., Willett, W. C., Phillips, K. M., Jacobs Jr., D. R. and Blomhoff, R. (2010). The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutrition Journal, 9, 3. https://doi.org/10.1186/1475-2891-9-3
de Castro Campos Pinto, N. and Scio, E. (2014). The Biological Activities and Chemical Composition of Pereskia Species (Cactaceae)—A Review. Plant Foods for Human Nutrition, 69, 189-195. https://doi.org/10.1007/s11130-014-0423-z
Chan, Y. S., Cheah, Y. H., Chong, P. Z., Khor, H. L., Teh, W. S., Khoo, K. S., Ong, H. C. and Sit, N. W. (2018). Antifungal and cytotoxic activities of selected medicinal plants from Malaysia. Pakistan Journal of Pharmaceutical Sciences, 31(1), 119-127.
Er, H. M., Cheng, E-H. and Radhakrishnan, A. K. (2007). Anti-proliferative and mutagenic activities of aqueous and methanol extracts of leaves from Pereskia bleo (Kunth) DC (Cactaceae). Journal of Ethnopharmacology, 113(3), 448-456. https://doi.org/10.1016/j.jep.2007.06.026
Félix-Silva, J., Silva-Junior, A. A., Zucolotto, S. M. and de Freitas Fernandes-Pedrosa, M. (2017). Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence. Evidence-Based Complementary and Alternative Medicine, 574826. https://doi.org/10.1155/2017/5748256
Garcia, J. A. A., Corrêa, R. C. G., Barros, L., Pereira, C., Abreu, R. M. V., Alves, M. J., Calhelha, R. C., Bracht, A., Peralta, R. M. and Ferreira, I. C. F. R. (2019). Phytochemical profile and biological activities of “Ora-pro-nobis’ leaves (Pereskia aculeata Miller), an, underexploited superfood from the Brazilian Atlantic Forest. Food Chemistry, 294, 302-308. https://doi.org/10.1016/j.foodchem.2019.05.074
Guilhon, C. C., Wahab, I. R. A., Boylan, F. and Fernandes, P. D. (2015). Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds. Evidence-Based Complementary and Alternative Medicine, 915927. https://doi.org/10.1155/2015/915927
Gupta, M. P., Correa A., M. D., Solis, P. N., Jones, A., Galdames, C. and Guionneau-Sinclair, F. (1993). Medicinal plant inventory of Kuna Indians: Part 1. Journal of Ethnopharmacology, 40(2), 77-109. https://doi.org/10.1016/0378-8741(93)90054-9
Gupta, R., Mishra, P. S., Kala, N., Pai, A. and Malviya, R. (2021). Therapeutic Potential of Herbal Molecules against Breast Cancer. Current Nutrition and Food Science, 17(7), 652-661. https://doi.org/10.2174/1573401317666210111110556
Johari, M. A. and Khong, H. Y. (2019). Total Phenolic Content and Antioxidant and Antibacterial Activities of Pereskia bleo. Advances in Pharmacological and Pharmaceutical Sciences, 7428593. https://doi.org/10.1155/2019/7428593
Lekshmi, S. G., Shruti, S., Pooja, B. K., Swarajya, L. N. and Menaka, M. (2023). Ornamental plant extracts: Application in food colouration and packaging, antioxidant, antimicrobial and pharmacological potential—A concise review. Food Chemistry Advances, 3, 100529. https://doi.org/10.1016/j.focha.2023.100529
Lim, S-L. and Mohamed, S. (2016). Functional food and dietary supplements for lung health. Trends in Food Science and Technology, 57A, 74-82. https://doi.org/10.1016/j.tifs.2016.08.006
López-Barraza, D., Ortega-Ramos, A., Toregroza-Fuentes, E., Quintana, S. E. and García-Zapateiro, L. A. (2021). Rheological and Functional Properties of Hydrocolloids from Pereskia bleo Leaves. Fluids, 6(10), 349. https://doi.org/10.3390/fluids6100349
Malek, S. N. A., Shin, S. K., Wahab, N. A. and Yaacob, H. (2009). Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves. Molecules, 14(5), 1713-1724. https://doi.org/10.3390/molecules14051713
Mat Darus, N. A. and Mohamad, J. (2017). Antidiabetic Activity of Pereskia Bleo Aqueous Extracts in Alloxan Induced Diabetic Rats. Open Acces Journal of Pharmaceutical Research, 1(7). https://doi.org/10.23880/oajpr-16000137
Mohd-Salleh, S. F., Ismail, N., Wan-Ibrahim, W. S. & Ismail, T. N. N. T. (2020). Phytochemical Screening and Cytotoxic Effects of Crude Extracts of Pereskia Bleo Leaves. Journal of Herbs, Spices and Medicinal Plants, 26(3), 291-302. https://doi.org/10.1080/10496475.2020.1729287
do Nascimento Magalhães, K., Guarniz, W. A. S., Sá, K. M., Freire, A. B., Monteiro, M. P., Nojosa, R. T., Bieski, I. G. C., Custódio, J. B., Balogun, S. O. and Bandeira, M. A. M. (2019). Medicinal plants of the Caatinga, northeastern Brazil, Ethnopharmacopeia (1980-1990) of the late professor Francisco José de Abreu Matos. Journal of Ethnopharmacology, 237, 314-353. https://doi.org/10.1016/j.jep.2019.03.032
Ng, T. P., Wong, M. L., Hong, C. Y., Koh, K. T. C. and Goh, L. G. (2003). The use of complementary and alternative medicine by asthma patients. QJM: An International Journal of Medicine, 96(10), 747-754. https://doi.org/10.1093/qjmed/hcg121
Nikolic, J. S., Mitic, V. D., Jovanovic, V. P. S., Dimitrijevic, M. V. and Stojanovic, G. S. (2019). Chemometric characterization of twenty three culinary herbs and spices according to antioxidant activity. Journal of Food Measurement and Characterization, 13, 2167-2176. https://link.springer.com/article/10.1007/s11694-019-00137-0
Parveen, A., Akash, M. S. H., Rehman, K. and Kyunn, W. W. (2016). Anticancer Activities of Medicinal Plants: Modulation of p53 Expression and Induction of Apoptosis. Critical Reviews in Eukaryotic Gene Expression, 26(3), 257-271. https://doi.org/10.1615/critreveukaryotgeneexpr.2016016683
Philip, K., Malek, S. N. A., Sani, W., Shin, S. K., Kumar, S., Lai, H. S., Serm, L. G. and Rahman, S. N. S. A. (2009). Antimicrobial Activity of Some Medicinal Plants from Malaysia. American Journal of Applied Sciences, 6(8), 1613-1617. https://doi.org/10.3844/ajassp.2009.1613.1617
Rahman, H. A., Saari, N., Abas, F., Ismail, A., Mumtaz, M. W. and Hamid, A. A. (2017). Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds. International Journal of Food Properties, 20(11), 2616-2629. https://doi.org/10.1080/10942912.2016.1247098
Saptarini, N. M., Mustarichie, R., Herawati, I. E. and Hadisoebroto, G. (2022). Isolation, Identification, and Quantification of Major Flavonoid in Leaves of Pereskia bleo (Kunth) DC. International Journal of Applied Pharmaceutics, 14(4), 106-110. https://doi.org/10.22159/ijap.2022.v14s4.PP19
Sharif, K. M., Rahman, M. M., Azmir, J., Khatib, A., Hadijah, S. Mohamed, A., Sahena, F. and Zaidul, I. S. M. (2014). Orthogonal Partial Least Squares Model for Rapid Prediction of Antioxidant Activity of Pereskia bleo by Fourier Transform Infrared Spectroscopy. Analytical Letters 47(12), 2061-2071. https://doi.org/10.1080/00032719.2014.898150
Sharif, K. M., Rahman, M. M., Azmir, J., Khatib, A., Sabina, E., Shamsudin, S. H. and Zaidul, I. S. M. (2015a). Multivariate analysis of PRISMA optimized TLC image for predicting antioxidant activity and identification of contributing compounds from Pereskia bleo. Biomedical Chromatography, 29(12), 1826-1833. https://doi.org/10.1002/bmc.3503
Sharif, K. M., Rahman, M. M., Azmir, J., Shamsudin, S. H., Uddin, M. S., Fahim, T. K. and Zaidul, I. S. M. (2015b). Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo. Journal of Industrial and Engineering Chemistry, 21, 1314-1322. https://doi.org/10.1016/j.jiec.2014.05.047
Sharif, K. M., Rahman, M. M., Zaidul, I. S. M., Jannatul, A., Akanda, M. J. H., Mohamed, A. and Shamsudin, S. H. (2013). Pharmacological Relevance of Primitive Leafy Cactuses Pereskia. Research Journal of Biotechnology, 8(12), 134-142.
Siew, Y-Y., Yew, H-C., Neo, S-Y., Seow, S-V., Lew, S-M., Lim, S-W., Lim, C. S. E-S., Ng, Y-C., Seetoh, W-G., Ali, A., Tan, C-H. and Koh, H-L. (2019). Evaluation of anti-proliferative activity of medicinal plants used in Asian Traditional Medicine to treat cancer. Journal of Ethnopharmacology, 235, 75-87. https://doi.org/10.1016/j.jep.2018.12.040
Sim, K. S., Nurestri, A. M. S. and Norhanom, A. W. (2010). Phenolic content and antioxidant activity of crude and fractionated extracts of Pereskia bleo (Kunth) DC. (Cactaceae). African Journal of Pharmacy and Pharmacology, 4(5), 193-201. https://doi.org/10.5897/AJPP.9000222
Siska, S., Hanani, E., Bariroh, T., Febrianto, B., Pratiwi, A. D. A. P., Yaner, N. N. and Fitri, N. A. (2023). Effect of the ethanol extract of Pereskia bleo (Kunth) DC on the blood pressure and electrolyte levels of hypertensive rats. Journal of Herbmed Pharmacology, 12(3), 448-452. https://doi.org/10.34172/jhp.2023.50
Takeiti, C. Y., Antonio, G. C., Motta, E. M. P., Collares-Queiroz, P. and Park, K. J. (2009). International Journal of Food Sciences and Nutrition, 60(sup1), 148-160. https://doi.org/10.1080/09637480802534509
Tan, M. L., Sulaiman, S. F., Najimuddin, N., Samian, M. R. and Muhammad, T. S. T. (2005). Methanolic extract of Pereskia bleo (Kunth) DC (Cactaceae) induces apoptosis in breast carcinoma, T47-D cell line. Journal of Ethnopharmacology, 96(1-2), 287-294. https://doi.org/10.1016/j.jep.2004.09.025
Wan-Nadilah, W. A., Khozirah, S., Khatib, A., Hamid, A. A. and Hamid, M. (2019). Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes. International Food Research Journal, 26(1), 75-85.
Zareisedehizadeh, S., Siew, Y-Y., Wee, H-L., Tan, C-H. and Koh, H-L. (2022). Medicinal uses of a leafy cactus, Pereskia bleo, in Singapore: A survey on the users’ knowledge and their perceptions. International Journal of Herbal Medicine, 10(1A), 1-7. https://doi.org/10.22271/flora.2022.v10.i1a.788
Zareisedehizadeh, S., Tan, C-H. and Koh, H-L. (2014). A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC. Evidence-Based Complementary and Alternative Medicine, 326107. https://doi.org/10.1155/2014/326107
Natasya Hermawan